| 5/16/2024 | Jane Street Group LLC | 633,932 | $13.52M | 0.0% | +2,153.4% | 0.745% | |
| 5/16/2024 | California State Teachers Retirement System | 39,041 | $832K | 0.0% | N/A | 0.046% | |
| 5/16/2024 | KRYGER CAPITAL Ltd | 100,284 | $2.14M | 0.4% | N/A | 0.118% | |
| 5/16/2024 | Beryl Capital Management LLC | 16,191 | $345K | 0.4% | N/A | 0.019% | |
| 5/15/2024 | GABELLI & Co INVESTMENT ADVISERS INC. | 115,750 | $2.47M | 0.4% | N/A | 0.136% | |
| 5/15/2024 | Gabelli Funds LLC | 146,150 | $3.12M | 0.0% | N/A | 0.172% | |
|
| 5/15/2024 | Gamco Investors INC. ET AL | 11,450 | $244K | 0.0% | N/A | 0.013% | |
| 5/14/2024 | Natixis | 99,000 | $2.11M | 0.0% | N/A | 0.116% | |
| 5/10/2024 | Maso Capital Partners Ltd | 150,000 | $3.20M | 2.4% | N/A | 0.177% | |
| 5/9/2024 | Chicago Capital Management LLC | 170,200 | $3.63M | 3.8% | N/A | 0.201% | |
| 5/9/2024 | Blair William & Co. IL | 779,202 | $16.61M | 0.1% | -21.6% | 0.918% | |
| 5/8/2024 | ProShare Advisors LLC | 17,623 | $376K | 0.0% | N/A | 0.021% | |
| 5/7/2024 | Swiss National Bank | 85,700 | $1.83M | 0.0% | N/A | 0.101% | |
| 4/30/2024 | Privium Fund Management B.V. | 251,158 | $5.36M | 1.5% | +77.2% | 0.296% | |
| 4/29/2024 | China Universal Asset Management Co. Ltd. | 13,920 | $297K | 0.0% | +66.2% | 0.016% | |
| 3/5/2024 | Wellington Management Group LLP | 744,474 | $7.15M | 0.0% | N/A | 1.028% | |
| 2/15/2024 | Forefront Analytics LLC | 16,715 | $161K | 0.1% | -50.4% | 0.023% | |
| 2/14/2024 | Avidity Partners Management LP | 6,500,328 | $62.47M | 2.3% | +12.4% | 8.978% | |
| 2/14/2024 | Superstring Capital Management LP | 45,801 | $440K | 0.3% | N/A | 0.063% | |
| 2/13/2024 | Tower Research Capital LLC TRC | 3,008 | $29K | 0.0% | +2,064.0% | 0.004% | |
| 2/13/2024 | NEOS Investment Management LLC | 30,939 | $297K | 0.0% | +76.9% | 0.043% | |
| 2/7/2024 | Jump Financial LLC | 86,199 | $828K | 0.0% | N/A | 0.119% | |
| 2/1/2024 | New York State Common Retirement Fund | 6,630 | $64K | 0.0% | N/A | 0.009% | |
| 2/1/2024 | Jennison Associates LLC | 301,020 | $2.89M | 0.0% | N/A | 0.416% | |
| 2/1/2024 | Signaturefd LLC | 2,949 | $28K | 0.0% | +883.0% | 0.004% | |
| 1/31/2024 | abrdn plc | 21,697 | $209K | 0.0% | N/A | 0.030% | |
| 1/31/2024 | Federated Hermes Inc. | 10,886,153 | $104.62M | 0.3% | +1.9% | 15.034% | |
| 1/30/2024 | HealthInvest Partners AB | 125,000 | $1.20M | 0.9% | N/A | 0.173% | |
| 1/24/2024 | China Universal Asset Management Co. Ltd. | 8,376 | $80K | 0.0% | N/A | 0.012% | |
| 1/16/2024 | Raymond James Financial Services Advisors Inc. | 31,145 | $299K | 0.0% | N/A | 0.043% | |
| 1/12/2024 | Yarbrough Capital LLC | 76,872 | $739K | 0.0% | N/A | 0.106% | |
| 11/14/2023 | Avidity Partners Management LP | 5,781,850 | $15.03M | 0.6% | +1.4% | 7.985% | |
| 11/13/2023 | Federated Hermes Inc. | 10,683,789 | $27.78M | 0.1% | +0.5% | 14.755% | |
| 11/13/2023 | FMR LLC | 4,177,848 | $10.86M | 0.0% | -10.8% | 5.770% | |
| 11/8/2023 | Forefront Analytics LLC | 33,685 | $88K | 0.0% | +67.8% | 0.049% | |
| 10/27/2023 | Eagle Health Investments LP | 579,769 | $1.51M | 0.3% | -14.8% | 0.840% | |
| 8/24/2023 | Perceptive Advisors LLC | 2,751,395 | $12.85M | 0.4% | -0.3% | 3.988% | |
| 8/15/2023 | Sphera Funds Management LTD. | 1,329,258 | $6.21M | 1.0% | +3.6% | 1.926% | |
| 8/14/2023 | Eagle Health Investments LP | 680,370 | $3.18M | 0.6% | N/A | 0.986% | |
| 8/11/2023 | Artal Group S.A. | 1,725,000 | $8.06M | 0.2% | -12.7% | 2.500% | |
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| 5/15/2023 | Ghost Tree Capital LLC | 350,000 | $1.32M | 0.4% | N/A | 0.554% | |
| 5/15/2023 | Sio Capital Management LLC | 246,036 | $928K | 0.5% | -5.5% | 0.389% | |
| 5/8/2023 | Federated Hermes Inc. | 5,849,100 | $22.05M | 0.1% | +81.4% | 9.253% | |
| 5/1/2023 | Virtu Financial LLC | 13,084 | $49K | 0.0% | N/A | 0.021% | |
| 2/15/2023 | Braidwell LP | 2,000,000 | $6.30M | 0.2% | N/A | 4.468% | |
| 2/10/2023 | Tekla Capital Management LLC | 43,394 | $137K | 0.0% | -57.4% | 0.097% | |
| 11/15/2022 | Federated Hermes Inc. | 3,174,100 | $9.56M | 0.0% | +1.6% | 7.091% | |
| 11/14/2022 | Point72 Asset Management L.P. | 310,068 | $933K | 0.0% | -5.7% | 0.693% | |
| 11/14/2022 | RA Capital Management L.P. | 659,992 | $1.99M | 0.0% | N/A | 1.474% | |
| 11/14/2022 | UBS Oconnor LLC | 17,286 | $52K | 0.0% | N/A | 0.039% | |
| 11/8/2022 | Sofinnova Investments Inc. | 117,099 | $352K | 0.0% | +50.0% | 0.270% | |
| 11/4/2022 | Prudential Financial Inc. | 14,600 | $44K | 0.0% | N/A | 0.034% | |
| 11/2/2022 | Victory Capital Management Inc. | 50,390 | $152K | 0.0% | -72.2% | 0.116% | |
| 11/1/2022 | Tekla Capital Management LLC | 101,931 | $605K | 0.0% | +134.9% | 0.235% | |
| 9/16/2022 | Federated Hermes Inc. | 3,124,100 | $7.78M | 0.0% | +2.3% | 7.200% | |
| 8/15/2022 | Pivotal bioVenture Partners Investment Advisor LLC | 1,560,982 | $3.89M | 2.0% | -2.3% | 3.597% | |
| 5/4/2022 | Victory Capital Management Inc. | 183,690 | $1.30M | 0.0% | -26.6% | 0.424% | |
| 2/25/2022 | AlphaCentric Advisors LLC | 100,000 | $417K | 0.1% | N/A | 0.232% | |
| 2/14/2022 | Perceptive Advisors LLC | 1,227,017 | $5.12M | 0.1% | -2.2% | 2.849% | |
| 2/14/2022 | Point72 Asset Management L.P. | 1,048,956 | $4.37M | 0.0% | +22.3% | 2.436% | |
| 2/7/2022 | Victory Capital Management Inc. | 250,380 | $1.04M | 0.0% | -6.5% | 0.581% | |
| 12/3/2021 | Perceptive Advisors LLC | 1,254,607 | $9.94M | 0.1% | -29.3% | 2.913% | |
| 11/15/2021 | Point72 Asset Management L.P. | 858,012 | $6.80M | 0.0% | -2.0% | 1.992% | |
| 11/15/2021 | Sectoral Asset Management Inc | 38,198 | $303K | 0.0% | N/A | 0.089% | |
| 11/12/2021 | Johnson & Johnson | 3,670,516 | $29.07M | 2.6% | N/A | 8.523% | |
| 11/9/2021 | BlackRock Inc. | 414,256 | $3.28M | 0.0% | -11.9% | 0.963% | |
| 11/2/2021 | Victory Capital Management Inc. | 267,703 | $2.12M | 0.0% | -0.7% | 0.622% | |
| 8/17/2021 | Woodline Partners LP | 154,597 | $1.25M | 0.0% | +24.1% | 0.364% | |
| 8/17/2021 | Perceptive Advisors LLC | 1,775,167 | $14.34M | 0.2% | -9.0% | 4.181% | |
| 8/16/2021 | Point72 Asset Management L.P. | 875,141 | $7.07M | 0.0% | +16.7% | 2.061% | |
| 8/16/2021 | Perceptive Advisors LLC | 1,775,167 | $14.34M | 0.2% | -9.0% | 4.181% | |
| 8/16/2021 | Federated Hermes Inc. | 597,841 | $4.83M | 0.0% | +5.8% | 1.408% | |
| 8/16/2021 | Goldman Sachs Group Inc. | 18,221 | $147K | 0.0% | +29.5% | 0.043% | |
| 8/13/2021 | Adams Street Partners LLC | 2,973,744 | $24.03M | 5.0% | -0.5% | 7.004% | |
| 8/13/2021 | FMR LLC | 3,184,209 | $25.73M | 0.0% | +1.5% | 7.500% | |
| 8/11/2021 | BlackRock Inc. | 470,303 | $3.80M | 0.0% | -41.8% | 1.108% | |
| 8/3/2021 | Victory Capital Management Inc. | 269,623 | $2.18M | 0.0% | -5.6% | 0.635% | |
| 5/18/2021 | Millennium Management LLC | 10,726 | $115K | 0.0% | -76.9% | 0.025% | |
| 5/18/2021 | Point72 Asset Management L.P. | 750,000 | $8.04M | 0.0% | +36.4% | 1.766% | |
| 5/18/2021 | Morgan Stanley | 76,171 | $817K | 0.0% | +90.7% | 0.179% | |
| 5/17/2021 | Perceptive Advisors LLC | 1,950,167 | $20.91M | 0.3% | -12.8% | 4.593% | |
| 5/17/2021 | Woodline Partners LP | 124,594 | $1.34M | 0.0% | +135.9% | 0.293% | |
| 5/13/2021 | Federated Hermes Inc. | 565,000 | $6.06M | 0.0% | +7.6% | 1.331% | |
| 5/10/2021 | Adams Street Partners LLC | 2,989,644 | $32.05M | 5.1% | -14.4% | 7.044% | |
| 5/7/2021 | BlackRock Inc. | 807,536 | $8.66M | 0.0% | -2.8% | 1.903% | |
| 5/7/2021 | Altfest L J & Co. Inc. | 10,139 | $109K | 0.0% | N/A | 0.024% | |
| 5/4/2021 | Victory Capital Management Inc. | 285,678 | $3.06M | 0.0% | +59.1% | 0.673% | |
| 3/12/2021 | DekaBank Deutsche Girozentrale | 13,000 | $155K | 0.0% | N/A | 0.031% | |
| 3/2/2021 | Norges Bank | 50,000 | $588K | 0.0% | N/A | 0.120% | |
| 2/16/2021 | Clough Capital Partners L P | 399,399 | $4.69M | 0.3% | -0.8% | 0.957% | |
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| 2/12/2021 | Caas Capital Management LP | 23,148 | $272K | 0.0% | -60.4% | 0.055% | |
| 2/12/2021 | Federated Hermes Inc. | 525,000 | $6.17M | 0.0% | +2.9% | 1.258% | |
| 2/9/2021 | Pivotal bioVenture Partners Investment Advisor LLC | 1,598,379 | $18.78M | 6.2% | N/A | 3.831% | |
| 2/5/2021 | BlackRock Inc. | 830,737 | $9.76M | 0.0% | +80.6% | 1.991% | |
| 2/1/2021 | Victory Capital Management Inc. | 179,524 | $2.11M | 0.0% | +18.4% | 0.430% | |
| 12/30/2020 | Deerfield Management Company L.P. Series C | 972,046 | $11.68M | 0.2% | -22.7% | 2.330% | |
| 11/13/2020 | Morgan Stanley | 26,693 | $321K | 0.0% | -96.0% | 0.064% | |
| 11/12/2020 | Federated Hermes Inc. | 510,000 | $6.13M | 0.0% | +59.4% | 1.224% | |
| 11/9/2020 | Caas Capital Management LP | 58,398 | $702K | 0.0% | -2.7% | 0.140% | |
| 11/9/2020 | Victory Capital Management Inc. | 151,608 | $1.82M | 0.0% | -17.5% | 0.364% | |
