| 11/15/2023 | Redmile Group LLC | 582,443 | $2.30M | 0.1% | -80.0% | 6.619% | |
| 11/15/2023 | Kynam Capital Management LP | 24,037 | $95K | 0.0% | -80.0% | 0.273% | |
| 11/15/2023 | Adage Capital Partners GP L.L.C. | 310,000 | $1.22M | 0.0% | N/A | 3.523% | |
| 10/23/2023 | BML Capital Management LLC | 98,664 | $390K | 0.4% | +315.4% | 1.121% | |
| 7/26/2023 | Privium Fund Management B.V. | 117,200 | $95K | 0.0% | N/A | 0.274% | |
| 5/15/2023 | MYDA Advisors LLC | 40,000 | $28K | 0.0% | N/A | 0.093% | |
|
| 5/9/2023 | US Bancorp DE | 44,346 | $31K | 0.0% | +111.2% | 0.104% | |
| 11/14/2022 | Point72 Asset Management L.P. | 2,064,222 | $1.32M | 0.0% | +43.6% | 4.848% | |
| 11/1/2022 | Privium Fund Management UK Ltd | 117,200 | $75K | 0.1% | N/A | 0.275% | |
| 8/15/2022 | Opaleye Management Inc. | 610,000 | $628K | 0.3% | -22.8% | 1.433% | |
| 8/9/2022 | Pictet Asset Management SA | 781,551 | $805K | 0.0% | -69.6% | 1.839% | |
| 8/8/2022 | Simon Quick Advisors LLC | 46,856 | $49K | 0.0% | N/A | 0.110% | |
| 7/27/2022 | Bailard Inc. | 90,100 | $93K | 0.0% | N/A | 0.212% | |
| 7/14/2022 | Adviser Investments LLC | 65,404 | $67K | 0.0% | +39.7% | 0.154% | |
| 5/12/2022 | Gyon Technologies Capital Management LP | 36,803 | $69K | 0.0% | N/A | 0.087% | |
| 5/11/2022 | ACT Capital Management LLC | 199,000 | $374K | 0.4% | -6.4% | 0.468% | |
| 5/4/2022 | Adviser Investments LLC | 46,817 | $88K | 0.0% | +347.6% | 0.110% | |
| 5/2/2022 | Allspring Global Investments Holdings LLC | 45,709 | $85K | 0.0% | N/A | 0.108% | |
| 2/14/2022 | PDT Partners LLC | 39,462 | $190K | 0.0% | +90.0% | 0.093% | |
| 2/14/2022 | Redmile Group LLC | 3,490,835 | $16.83M | 0.4% | -0.5% | 8.228% | |
| 2/14/2022 | Point72 Asset Management L.P. | 1,010,790 | $4.87M | 0.0% | +1.1% | 2.382% | |
| 2/14/2022 | GSA Capital Partners LLP | 130,899 | $631K | 0.1% | +73.6% | 0.309% | |
| 2/11/2022 | Renaissance Technologies LLC | 843,612 | $4.07M | 0.0% | +11.5% | 1.988% | |
| 2/10/2022 | Pictet Asset Management SA | 2,574,289 | $12.41M | 0.0% | -3.4% | 6.067% | |
| 2/10/2022 | Acadian Asset Management LLC | 23,405 | $112K | 0.0% | N/A | 0.055% | |
| 2/8/2022 | Northern Trust Corp | 326,497 | $1.57M | 0.0% | -7.1% | 0.770% | |
| 2/3/2022 | Los Angeles Capital Management LLC | 51,453 | $248K | 0.0% | +20.7% | 0.121% | |
| 2/3/2022 | ACT Capital Management LLC | 212,500 | $1.02M | 0.7% | -11.1% | 0.501% | |
| 2/2/2022 | New York State Common Retirement Fund | 14,396 | $69K | 0.0% | -57.2% | 0.034% | |
| 1/31/2022 | Adviser Investments LLC | 10,460 | $50K | 0.0% | N/A | 0.025% | |
| 1/21/2022 | Kestra Private Wealth Services LLC | 12,000 | $58K | 0.0% | N/A | 0.028% | |
| 1/21/2022 | Pinnacle Wealth Planning Services Inc. | 14,303 | $69K | 0.0% | N/A | 0.034% | |
| 11/22/2021 | EcoR1 Capital LLC | 860,619 | $6.22M | 0.2% | -63.5% | 2.028% | |
| 11/16/2021 | Opaleye Management Inc. | 1,047,300 | $7.57M | 1.4% | -9.4% | 2.468% | |
| 11/16/2021 | Two Sigma Advisers LP | 174,600 | $1.26M | 0.0% | +192.5% | 0.412% | |
| 11/16/2021 | Two Sigma Investments LP | 120,212 | $869K | 0.0% | +207.5% | 0.283% | |
| 11/16/2021 | Metropolitan Life Insurance Co NY | 4,698 | $34K | 0.0% | -52.4% | 0.011% | |
| 11/15/2021 | Point72 Asset Management L.P. | 1,000,000 | $7.23M | 0.0% | +13.2% | 2.357% | |
| 11/15/2021 | Marshall Wace LLP | 19,421 | $140K | 0.0% | N/A | 0.046% | |
| 11/15/2021 | Granahan Investment Management Inc. MA | 125,331 | $906K | 0.0% | -35.8% | 0.295% | |
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| 11/15/2021 | GSA Capital Partners LLP | 75,419 | $545K | 0.1% | N/A | 0.178% | |
| 11/12/2021 | Trexquant Investment LP | 34,300 | $248K | 0.0% | +141.4% | 0.081% | |
| 11/12/2021 | Renaissance Technologies LLC | 756,892 | $5.47M | 0.0% | +31.4% | 1.784% | |
| 11/12/2021 | Macquarie Group Ltd. | 11,960 | $86K | 0.0% | +2,208.9% | 0.028% | |
| 11/12/2021 | The Manufacturers Life Insurance Company | 11,580 | $84K | 0.0% | -45.8% | 0.027% | |
| 11/12/2021 | Geode Capital Management LLC | 617,827 | $4.47M | 0.0% | +6.0% | 1.456% | |
| 11/10/2021 | Goldman Sachs Group Inc. | 117,656 | $850K | 0.0% | -43.6% | 0.277% | |
| 11/10/2021 | Citigroup Inc. | 6,773 | $49K | 0.0% | -88.6% | 0.016% | |
| 11/9/2021 | BlackRock Inc. | 2,669,276 | $19.30M | 0.0% | +1.2% | 6.291% | |
| 11/9/2021 | Candriam Luxembourg S.C.A. | 858,173 | $6.20M | 0.0% | +67.6% | 2.023% | |
| 11/8/2021 | Los Angeles Capital Management LLC | 42,633 | $308K | 0.0% | -8.0% | 0.100% | |
| 11/2/2021 | New York State Common Retirement Fund | 33,672 | $243K | 0.0% | -27.9% | 0.079% | |
| 11/1/2021 | SG Americas Securities LLC | 22,340 | $162K | 0.0% | N/A | 0.053% | |
| 8/17/2021 | Metropolitan Life Insurance Co NY | 9,870 | $91K | 0.0% | +98,600.0% | 0.023% | |
| 8/17/2021 | Millennium Management LLC | 157,971 | $1.46M | 0.0% | +7.9% | 0.372% | |
| 8/17/2021 | MetLife Investment Management LLC | 14,552 | $134K | 0.0% | +281.3% | 0.034% | |
| 8/17/2021 | Price T Rowe Associates Inc. MD | 35,534 | $328K | 0.0% | +16.1% | 0.084% | |
| 8/16/2021 | Bank of America Corp DE | 184,214 | $1.70M | 0.0% | +481.9% | 0.434% | |
| 8/16/2021 | UBS Asset Management Americas Inc. | 10,340 | $95K | 0.0% | N/A | 0.024% | |
| 8/16/2021 | Point72 Asset Management L.P. | 883,102 | $8.15M | 0.0% | -32.5% | 2.082% | |
| 8/16/2021 | Cubist Systematic Strategies LLC | 5,499 | $51K | 0.0% | +399.9% | 0.013% | |
| 8/16/2021 | Opaleye Management Inc. | 1,156,200 | $10.67M | 1.8% | -5.6% | 2.725% | |
| 8/16/2021 | Redmile Group LLC | 3,919,235 | $36.18M | 0.5% | -4.8% | 9.238% | |
| 8/16/2021 | Morgan Stanley | 631,008 | $5.82M | 0.0% | +82.5% | 1.487% | |
| 8/16/2021 | Charles Schwab Investment Management Inc. | 88,594 | $818K | 0.0% | +7.3% | 0.209% | |
| 8/16/2021 | State Street Corp | 1,235,098 | $11.40M | 0.0% | -21.8% | 2.911% | |
| 8/16/2021 | Goldman Sachs Group Inc. | 208,717 | $1.93M | 0.0% | -38.3% | 0.492% | |
| 8/13/2021 | Renaissance Technologies LLC | 575,992 | $5.32M | 0.0% | -6.8% | 1.358% | |
| 8/13/2021 | Northern Trust Corp | 364,492 | $3.36M | 0.0% | -2.5% | 0.859% | |
| 8/13/2021 | Qube Research & Technologies Ltd | 16,385 | $151K | 0.0% | N/A | 0.039% | |
| 8/13/2021 | Geode Capital Management LLC | 582,625 | $5.38M | 0.0% | +8.4% | 1.373% | |
| 8/13/2021 | Vanguard Group Inc. | 1,593,582 | $14.71M | 0.0% | +5.0% | 3.756% | |
| 8/13/2021 | ProShare Advisors LLC | 16,743 | $155K | 0.0% | +16.2% | 0.039% | |
| 8/12/2021 | Trexquant Investment LP | 14,211 | $131K | 0.0% | N/A | 0.033% | |
| 8/12/2021 | Dimensional Fund Advisors LP | 37,145 | $343K | 0.0% | +153.4% | 0.088% | |
| 8/12/2021 | JPMorgan Chase & Co. | 16,267 | $151K | 0.0% | +33.9% | 0.038% | |
| 8/12/2021 | The Manufacturers Life Insurance Company | 21,349 | $197K | 0.0% | +12.2% | 0.050% | |
| 8/11/2021 | BlackRock Inc. | 2,638,758 | $24.36M | 0.0% | -2.6% | 6.220% | |
| 8/10/2021 | State Board of Administration of Florida Retirement System | 19,092 | $176K | 0.0% | +19.5% | 0.045% | |
| 8/10/2021 | Citigroup Inc. | 59,211 | $547K | 0.0% | -32.7% | 0.140% | |
| 8/10/2021 | Rafferty Asset Management LLC | 36,258 | $335K | 0.0% | -48.1% | 0.086% | |
| 8/6/2021 | Swiss National Bank | 73,900 | $682K | 0.0% | +11.8% | 0.175% | |
| 8/5/2021 | Rhumbline Advisers | 50,457 | $466K | 0.0% | +43.3% | 0.119% | |
| 8/5/2021 | Los Angeles Capital Management LLC | 46,363 | $428K | 0.0% | +69.2% | 0.109% | |
| 8/2/2021 | New York State Common Retirement Fund | 46,677 | $431K | 0.0% | -9.5% | 0.110% | |
| 7/31/2021 | Personal CFO Solutions LLC | 23,710 | $219K | 0.0% | +26.7% | 0.056% | |
| 7/30/2021 | Alliancebernstein L.P. | 26,400 | $244K | 0.0% | +18.9% | 0.062% | |
| 5/18/2021 | Millennium Management LLC | 146,349 | $1.80M | 0.0% | +2.4% | 0.346% | |
| 5/18/2021 | Opaleye Management Inc. | 1,225,000 | $15.08M | 2.2% | -11.6% | 2.893% | |
| 5/18/2021 | Point72 Asset Management L.P. | 1,308,600 | $16.11M | 0.1% | +9.4% | 3.090% | |
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| 5/18/2021 | Morgan Stanley | 345,671 | $4.26M | 0.0% | -19.7% | 0.816% | |
| 5/18/2021 | Redmile Group LLC | 4,117,569 | $50.69M | 0.7% | -0.3% | 9.724% | |
| 5/17/2021 | Royal Bank of Canada | 9,483 | $117K | 0.0% | +14.6% | 0.022% | |
| 5/17/2021 | Price T Rowe Associates Inc. MD | 30,594 | $377K | 0.0% | +52.4% | 0.072% | |
| 5/17/2021 | Ameriprise Financial Inc. | 14,190 | $175K | 0.0% | N/A | 0.034% | |
| 5/17/2021 | Nuveen Asset Management LLC | 141,881 | $1.75M | 0.0% | -52.8% | 0.335% | |
| 5/17/2021 | Goldman Sachs Group Inc. | 338,530 | $4.17M | 0.0% | +1,091.0% | 0.799% | |
| 5/14/2021 | Dimensional Fund Advisors LP | 14,658 | $180K | 0.0% | -94.0% | 0.035% | |
| 5/14/2021 | Credit Suisse AG | 17,612 | $216K | 0.0% | -58.2% | 0.042% | |
| 5/13/2021 | Renaissance Technologies LLC | 617,937 | $7.61M | 0.0% | -19.0% | 1.460% | |
